Comparing the similarities and differences between medication and non medication treatment in patien
Any discrepancies between the authors were resolved through mutual discussions with the other authors C.
Are generic drugs less effective?
The study provides the best available evidence on the comparative efficacy and safety of non-insulin anti-diabetic agents on top of pre-existing insulin therapy for inadequately controlled T2DM patients. We obtained information from the ClinicalTrials. Natural history transitional probabilities We did not find Norwegian data compatible to the developed model, so the transitional probabilities are based on estimates reported in the published literature. These drugs may have side effects, including gas and diarrhea. The result of their study indicated that 8. Costs associated with MS care exclusive costs associated with interventions The costs associated with different health states EDSS levels , and relapse mild and severe were obtained from a Norwegian survey study carried out in , and including MS patients [ 26 ]. You should know that alcohol and some diabetes pills may not mix. The costs included in the model are drug costs, monitoring costs associated with the use of drugs, costs related to MS patients care excluding drugs at different EDSS levels, and costs related to the treatments of relapses and PML Table 2. The primary outcome was the change in glycated hemoglobin A1c HbA1c from baseline. The difference in the mean number of DTPs in eligible and ineligible patients ranged from 2. Introduction Impaired insulin secretion in the presence of insulin resistance is the key feature of type 2 diabetes mellitus T2DM. The average age of the patients was
The difference in the mean number of DTPs in eligible and ineligible patients ranged from 2. Therefore, as an alternative to more intensive insulin therapy, a non-insulin anti-diabetic drug may be used as an add-on drug to insulin therapy.
We estimated the surface under the cumulative ranking curve 11 for each treatment for each outcome, which provides the probability for each treatment to be ranked as the most effective treatment or to have the highest chance for a respective adverse event.
This means that all uncertain parameters treatment efficacy, costs, epidemiological data, etc. We also excluded studies with patients treated using an insulin pump.
The excluded publications including reasons for the exclusions are given in Supplementary material 9 www. Methods We conducted a systematic review and network meta-analysis following a pre-developed protocol Supplementary Appendix 1.
based on 82 review